Extending this strategy, immune-homeostatic microparticles co-presenting FasL and MCP-1 (a monocyte-attracting chemokine), loaded with the diabetes-associated autoantigen GAD524–543, were shown to induce T cell apoptosis and expand regulatory T cells in hyperglycemic NOD/ShiLtJ mice, preventing diabetes progression via antigen-specific immune tolerance (132). The gene discussed is CCL2; the disease is diabetes mellitus.