Comparing Ho:YAG with 270 μm‐CDF, TFL with 150 μm‐CDF and p‐Tm:YAG with 200 μm‐CDF, p‐Tm:YAG presented higher AR compared to TFL and Ho:YAG against HSP and SSP, except in Dusting against HSP for which TFL presented the highest ARs (p < 0,0001, and 0,02, respectively) (Table 2b). The gene discussed is HSP90B2P; the disease is hereditary spastic paraplegia.