IFNA1 and neoplasm: The inherent ability of NANPs to induce interferon responses when delivered using a lipid-based vehicle may overcome barriers created by dysfunctional antigen presentation machinery because IFNω can activate natural killer (NK) cells involved in direct killing of tumor cells, IFNα and IFNβ activate dendritic cells involved in antigen processing and presentation whereas IFNλ and IFNγ activate both APCs and T-cells127.