CISD1 and acute lymphoblastic leukemia: In contrast, CISD1 showed significant negative correlation with ESTIMATEscore in DLBC, TGCT, acute lymphocytic leukemia, LGG, GBMLGG, UCES, THCA, STES, COAD, LUAD, STAD, COADREAD, and SKCM (Fig. 7C), suggesting that CISD1 may be involved in creating a less dense TME.