Figure 5G showed strong positive correlations between CISD1 and RNA modifications like m1A, m5C, and m6A, indicating that CISD1 could serve as a biomarker for cancer prognosis, as high CISD1 expression, along with altered RNA modifications, might be associated with more aggressive tumor behavior and could predict poor outcomes in certain cancers including KICH, BRCA, LIHC, LUAD, and SKCM. The gene discussed is CISD1; the disease is cancer.