Interestingly, CISD1 mRNA expression levels were negatively correlated with age in CHOL, GBM, READ, CESC, PAAD, GBMLGG, TGCT, COADREAD, COAD, OV, BRCA, LGG, and LUSC (Fig. S3A), suggesting that younger patients have higher mRNA levels of CISD1 in these cancers, further supporting the above results that CISD1 is associated with bioenergetics. The gene discussed is CISD1; the disease is cancer.