CISD1 and central nervous system cancer: In contrast, higher CISD1 expression was significantly associated with lower risk of death in GBMLGG (Glioma) (HR = 0.54, p = 5.8e-8), LGG (HR = 0.52, p = 8.3e-5), and NB (Neuroblastoma) (HR = 0.58, p = 0.01) (Fig. 4A).