In contrast, CISD1 was significantly and negatively correlated with immune cells infiltration in STES, ESCA, STAD, GBMLGG, DLBC, THYM, and TGCT, suggesting that CISD1 might contribute to immune suppression and tumor evasion, and tumors with high CISD1 expression may be more resistant to immunotherapies in these cancers. The gene discussed is CISD1; the disease is cancer.