Conversely, CISD1 expression was down-regulated in 6 tumor tissues: bladder urothelial carcinoma (BLCA), glioblastoma multiforme (GBM), acute myeloid leukemia (LAML), sarcoma (SARC), testicular germ cell tumors (TGCT), thyroid carcinoma (THCA) (Fig. 1C), suggesting that CISD1 may play tumor suppressive functions in these cancers. Here, CISD1 is linked to cancer.