Figure S4A showed that CISD1 was positively correlated with immune chemokines in BLCA, BRCA, CESC, GBM, HNSC, LUSC, MESO, OV, SARC, THCA, and UCS, suggesting that higher CISD1 expression might promote chemokine expression, potentially influencing immune cell recruitment. Figure S4B showed that CISD1 was positively correlated with MHC genes in BLCA, BRCA, CESC, CHOL, GBM, HNSC, KIRC, KIRP, LIHC, LUSC, MESO, OV, SARC, THCA, and UCS, suggesting that high CISD1 expression is associated with up-regulated MHC gene expression, potentially enhancing antigen presentation and immune recognition. This evidence concerns the gene HLA-C and bladder transitional cell carcinoma.