Conversely, CISD1 expression was down-regulated in 6 tumor tissues: bladder urothelial carcinoma (BLCA), glioblastoma multiforme (GBM), acute myeloid leukemia (LAML), sarcoma (SARC), testicular germ cell tumors (TGCT), thyroid carcinoma (THCA) (Fig. 1C), suggesting that CISD1 may play tumor suppressive functions in these cancers. This evidence concerns the gene CISD1 and acute myeloid leukemia.