From the survival heatmaps and the corresponding Kaplan–Meier survival curves, high CISD1 expression is associated with worse patient survival (Fig. 4B) for ACC, HR = 2.8, p = 0.0061; BLCA, HR = 1.5, p = 0.0082; BRCA, HR = 1.6, p = 0.009; KICH, HR = 4, p = 0.02; LAML, HR = 1.9, p = 0.025; LIHC, HR = 2.1, p = 5.7e-05; LUAD, HR = 1.6, p = 0.003); MESO, HR = 2.2, p = 0.004; THCA, HR = 3.5, p = 0.0081; and THYM, HR = 5.7, p = 0.0075. This evidence concerns the gene CISD1 and adrenal cortex carcinoma.