,10 Nutrient-deprivation autophagy factor-1 (NAF-1/CISD2) is found in the outer mitochondrial membrane, endoplasmic reticulum, and mitochondria-associated membranes, and it links mitochondrial and endoplasmic reticulum functions, contributing to calcium signaling, autophagy, and apoptosis regulation; dysregulation of CISD2 is implicated in diseases like Wolfram syndrome and several cancers.8 Here, CISD2 is linked to Wolfram syndrome.