CISD1 and cancer: In addition, CISD1 may be important for metastasis in certain cancer types, as we found that CISD1 mRNA levels were increased in the M1 stage when compared with the M0 stage in BRCA and KIRC (Fig. S1B), and increased across different lymph node stages, from stage N0 to stage N3, in LUAD, BRCA, HNSC, LUSC, and READ (Fig. S1C); while decreased in COAD and THCA (Fig. S1C).