CISD1 and cancer: The relationship between CISD1 and these cancer-related factors can differ across cancer types due to variations in tumor genetic and epigenetic context and tumor microenvironment, as each cancer type has a unique set of genetic alterations and epigenetic modifications that can modulate how a gene interacts with other molecules and signaling pathways,78 and tumor microenvironment can alter gene function and expression, leading to different effects of a gene.79