Mechanistically, ADAMTS9-AS2 exerts its tumor suppressor functions by targeting the miR-182-5p/FOXF2,31 miR-223-3p/TGFBR3,21 miR-223-3p/NLRP3,24 miR-196b-5p/PPP1R12B,23 and miR-27a-3p/FOXO128 axis, or by mediating CDH3 promoter methylation.22 The gene discussed is TGFBR3; the disease is neoplasm.