ADAMTS9-AS2 is a functional tumor suppressor that inhibits tumor cell proliferation, invasion, and migration in multiple cancers,19 including lung cancer,20,21 esophageal cancer,22,23 gastric cancer,24,25 hepatocellular cancer,26 breast cancer,27 clear cell renal cell carcinoma,28 and bladder cancer,29,30 consistent with our previous findings in OSF and OSCC. Here, ADAMTS9-AS2 is linked to esophageal cancer.