Further studies assessing the longitudinal correlation between GAP-43 level and alterations of WM tracts detected by DTI or even more advanced MRI methods such as Diffusion Kurtosis Imaging (DKI) and High-Angular Resolution Diffusion Imaging (HARDI) can shed more light on our knowledge of the role of GAP-43 in predicting the progression of cognitive deficits in patients with AD spectrum. The gene discussed is GAP43; the disease is Cognitive impairment.