SNCA and Lewy body dementia: Although alpha-synuclein pathologic changes can affect HDAC expression,(30) and alpha-synuclein pathology is commonly observed in many of the brain regions demonstrating increased [11C]Martinostat uptake in DLB and PD, the changes in class HDAC I density observed here did not reliably coincide with the expected topography of alpha-synuclein pathology.