To discover new therapeutic targets, we leveraged RNA-Seq datasets generated at Moffitt from CD138+ MM cells derived from the bone marrow aspirates of newly diagnosed, relapsed/refractory patients, as well as those with monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMOL) (n = 813). Here, SDC1 is linked to Miyoshi myopathy.