Current literature reports that p53 mutants frequently gain oncogenic functions (Onc-p53), where the tumors or cancer cells require the presence of the mutated p53 allele for survival and proliferation (12, 14, 18, 55, 56), while, tumors or cancer cells with Onc-p53 mutation are often associated with chromosomal abnormalities as determined by copy number changes or aneuploidy (44, 45). This evidence concerns the gene TP53 and cancer.