The widely adopted ANG II infusion technique in Apoe−/− mice, has been repeatedly demonstrated to lead to aortic ruptures.16 While this model replicates hemodynamic and inflammatory changes associated with human AAA and achieves up to a 70% rupture rate when combined with 0.2% BAPN, a limitation of the traditional technique is that aortic ruptures often occur in the thoracic aorta rather than the infrarenal location as seen in the majority of human disease patterns. Here, APOE is linked to triple-A syndrome.