Lastly, among the spectrum of models designed to induce infrarenal AAA rupture, the use of Transforming Growth Factor-beta (TGF-β) blockade represents another interesting and promising approach.32 This model achieves a rupture rate of 40% by inhibiting the TGF-β pathway, which plays a critical role in tissue homeostasis and the inflammatory response. This evidence concerns the gene TGFB1 and triple-A syndrome.