AGT and triple-A syndrome: The widely adopted ANG II infusion technique in Apoe−/− mice, has been repeatedly demonstrated to lead to aortic ruptures.16 While this model replicates hemodynamic and inflammatory changes associated with human AAA and achieves up to a 70% rupture rate when combined with 0.2% BAPN, a limitation of the traditional technique is that aortic ruptures often occur in the thoracic aorta rather than the infrarenal location as seen in the majority of human disease patterns.