Finally, we sought to assess whether okanin targets at PRDX5 to inhibit cancer cell growth in nude mice model, for which we generated a stable PRDX5‐overexpressing cell line, hereby designated HCT116‐PRDX5 O.E. and the wild type cells as HCT116‐WT (Figure S7A, Supporting Information). Here, PRDX5 is linked to cancer.