PRDX5 and Familial prostate cancer: The N‐terminus of PRDX5 binds to other transcription factors, such as NRF2, which leads to the upregulation of NAPDH and attenuation of apoptosis via scavenging free radicals in non‐small‐cell lung cancer cells.[18] There is evidence that PRDX5 is increased in castration‐resistant prostate cancer cells, in which it mediates resistance to treatment by androgen receptor inhibitors.[19] The family member PRDX1 is a target of celastrol in the induction of colorectal cancer cell apoptosis.[20]