INS and obesity due to melanocortin 4 receptor deficiency: In agreement with our results, some researchers found that IPA treatment of human immortalized hepatocyte cells lowered cholesterol‐induced lipid accumulation in the cells.[67] Other studies have shown that the administration of 5‐HIAA improved glucose intolerance and obesity in HFD‐fed mice while preserving hepatic insulin sensitivity.[31] However, few studies on the correlation between 5‐HIAA and the progression of NAFLD have been conducted.