SDCBP and cancer: 2023). A high expression of Syntenin correlated with increased tumour growth and metastasis (Yang et al. 2013; Liu et al. 2018). On the cellular level, Syntenin has been associated with various cancer‐related processes, such as cell adhesion, migration, growth, proliferation, or immune evasion (Zimmermann et al. 2001; Kashyap et al. 2015; Liu et al. 2018). Moreover, Syntenin was identified as a key regulator for the biogenesis of a specific subclass of extracellular vesicles (EVs), the endosomal‐derived exosomes (Baietti et al. 2012).