TNF and non-small cell lung carcinoma: As expected, the DNA replication and cell cycle pathways were affected by the down regulated genes of FPGS silencing in A549 and H1975 cell lines (Figure 2B), although they were not at the top pathways as shown in GGH knockdown in Figure 1A, suggesting FPGS had other functions such as cellular senescence, TNF signaling, and NF‐kB, etc. Furthermore, the overlapped down‐regulated genes by siGGH and siFPGS were also involved in DNA replication and cell cycle pathways in NSCLC cell lines (Figure 2C), indicating these two genes have redundant roles in DNA replication and cell cycle.