Nilsson and colleagues conducted genome‐wide transcriptome and CpG methylation analysis in adipose tissue from patients with T2DM versus non‐diabetic subjects and found differential methylation at sites representing candidate T2DM genes, specifically IRS1, KCNQ1, TCF7L2 and PPARG [51]. The gene discussed is TCF7L2; the disease is type 2 diabetes mellitus.