SIRT1 and cardiac hypertrophy: The associated increased expression of Sirt‐1 is postulated to be a cardioprotective response to hyperglycaemic injury, as pharmacological activation of Sirt‐1 resulted in attenuation of cardiac hypertrophy and oxidative stress through a reduction in acetylation of NF‐kB‐p65 and global cardiac H3K9 levels in fructose‐fed diabetic rats [87].