Resorting integrated analyses from multi‐omics with public datasets, we systematically elucidated the underlying biological function and clinical characteristics of DDX family members in HCC, and DDX42, which had never been studied before in HCC, could play antiviral effects in various cell types [11] and take part in spliceosome assembly processes with DDX46 [12]. The gene discussed is DDX46; the disease is hepatocellular carcinoma.