CASP1 and polycystic ovary syndrome: Our research employed DHEA-induced PCOS mice in in vivo experiments and a caspase-3 inhibitor (Z-DEVD-FMK, ZDF) in cellular assays, along with a caspase-1 activity assay in KGN cells; cellular and in vivo data showed that IL2RG regulates pyroptosis via dual caspase pathways and is crucial in linking metabolic stress to PCOS pathogenesis.