CASP1 and polycystic ovary syndrome: Our research employed a caspase-3 inhibitor (ZDF) in cellular assays, along with a caspase-1 inhibitor VX-657 in KGN cells; the data from cellular and in vivo DHEA-induced PCOS mice showed that IL2RG regulates pyroptosis via dual caspase pathways and is crucial in linking metabolic stress to PCOS pathogenesis.