Our research employed a caspase-3 inhibitor (ZDF) in cellular assays, along with a caspase-1 inhibitor VX-657 in KGN cells; the data from cellular and in vivo DHEA-induced PCOS mice showed that IL2RG regulates pyroptosis via dual caspase pathways and is crucial in linking metabolic stress to PCOS pathogenesis. This evidence concerns the gene IL2RG and polycystic ovary syndrome.