Additionally, there was an increase in activated cytotoxic T cells (CTLs), including CD8+/IFN‐γ+, CD8+/IL‐2+, and CD8+/IL‐2+/IFN‐γ+ cells, in the spleen and tumour‐draining lymph nodes (Figure 3C–E). This evidence concerns the gene CD8A and neoplasm.