DNM2 and congenital heart disease: These genes seem generally to encode sarcomeric (contractile apparatus) or cytoskeletal proteins, although, in the case of left ventricular non-compaction with congenital heart disease, disturbance of the NOTCH signaling pathway seems part of a final common pathway for this form of the disease. More studies are needed to clarify the relationship between MMA and homocysteinemia and non-compaction of ventricular myocardium, as well as its prognosis.