In addition, other studies have shown that changes in downstream target genes mediated by STAT3 are closely related to cancer proliferation and metastasis.During the process of tumor cell metastasis, STAT3 can regulate the expression of ZEB1, SNAIL, and TWIST, and it is involved in the process of EMT (Xiong et al. 2012; Liu et al. 2021; Kim et al. 2014, 2019). This evidence concerns the gene ZEB1 and cancer.