CD4 and infection: In the present study, the WGCNA tan module that was enriched for T-cell differentiation and TCR rearrangement (both processes that were found to be upregulated by P. vivax asymptomatic carriers) positively correlated with populations of TH2 and TH17-polarized CD4+ T cells, predicting reduced and increased risk of symptomatic infection, respectively (Ioannidis et al, 2021).