NLRP3 and parasitic infectious disease: Whereas logistic regression analysis predicted dysregulation of critical transcriptional pathways controlling myeloid cell function, such as antigen presentation and TLR-associated signaling cascades during symptomatic P. vivax malaria, low parasitemia during asymptomatic infection appeared to be sufficient to compromise transcription of components required for formation and activation of the NLRP3 inflammasome.