CD8A and hypoparathyroidism-retardation-dysmorphism syndrome: Meanwhile, dysfunctional CD8+ T effector cells characterized by high expression of cytotoxic markers (GZMK) and exhausted markers (PD-1, CTLA4, LAG3, and TIGIT) are significantly enriched in the peritumoral stroma and tumor tissues of HGSOC patients with HRD [45].