Prior to tumor progression, the fallopian tube epithelial cells of BRCA1 mutation carriers upregulate genes related to oxidative phosphorylation (OXPHOS) and glycolysis, such as UQCRB and LDHB [95], compared with the WT population, indicating that BRCA1-deficient cells have considerably higher energy requirements than normal cells in the extremely early stage of HGSOC. This evidence concerns the gene BRCA1 and neoplasm.