The gene expression signatures observed are in line with previously defined microglial states in AD [94] showing a strong increase in DAM, interferon (IFN), major histocompatibility complex (MHC), and proliferation-associated gene expression and a reduction in homeostatic gene expression (Fig. S5E), confirming that between 4 and 8 months of age a strong induction of AD-associated microglial signatures is induced in APP-SAA KI mice. This evidence concerns the gene HLA-C and Alzheimer disease.