The addition of potential confounding by HbA1c, total cholesterol, HDLcc, LDLc, triglycerides, and CRP in the parental dementia instrument score model with each outcome showed consistent results to our main model on participants with complete data for these additional variables (+ 0.089, p = 0.003 to + 0.099, p = 0.001 for SBP, Additional file 1: Table S9; + 0.014, p = 0.402 to + 0.015, p = 0.381 for DBP, Additional file 1: Table S10; and OR = 1.018, p < 0.0001 to OR = 1.019, p < 0.0001 for hypertension, Additional file 1: Table-S11). The gene discussed is CRP; the disease is hypertensive disorder.