CAT and susceptibility to pneumonia measurement: To further investigate the relationships between BK channels, oxidative stress, and inflammatory molecules in our LPS-induced pneumonia model, we constructed a protein-drug interaction network using the STITCH database and integrating the following components: (i) BK channels (KCNMA1, the pore-forming α-subunit of the channel), (ii) the BK channel activating drugs NS1619/NS19504, (iii) the neutrophil/macrophage chemoattractants CCL-2, MIP-1α (CCL-3), and CXCL-10 cytokines, (iv) SOD1, and (v) catalase (Cat) (Fig. 5a).