CCL2 and van der Woude syndrome: I.t. administration of the BK channel activator NS1619 (0.66 mg/kg) at 0 and 24 h following LPS infection reversed LPS-induced total BALF cell counts and neutrophil infiltration into the alveolar space, CCL-2 secretion, cytosolic ROS production by BALF cells, and LIS parameters (Fig. 1a–f).