IL4 and Pruritus: Histological studies have shown that keloids exhibit an increase in mast cells, macrophages, lymphocytes, and neutrophils, and elevated levels of Th2 cytokines, including interleukin-4 (IL-4) and IL-13, which are implicated in pruritus; thereby suggesting a potential association with the exacerbation of pruritus3,7–10.