Bai et al. [61] demonstrated in triple-negative breast cancer cells that eIF2α phosphorylation promotes ATF4 activation, enabling it to transcriptionally regulate the glutamate-cysteine ligase catalytic subunit (GCLC) and SLC7A11, which are involved in the reverse transport of cystine and glutamate. This evidence concerns the gene GCLC and triple-negative breast carcinoma.