By lowering the amounts of ubiquitin-specific protease 4 (USP4) protein, METTL3 causes the ELAVL1 (embryonic lethal, abnormal vision, Drosophila-like 1) protein to degrade and increases the expression of Rho GDP dissociation inhibitor (GDI) alpha protein (ARHGDIA), thus promoting PCa cells migration and invasion [25, 26]. The gene discussed is ARHGDIA; the disease is posterior cortical atrophy.