THBS1 and neoplasm: In contrast, upregulation of METTL14 was correlated with poor prognosis in PCa patients, and knockdown of METTL14 inhibited tumor proliferation both in vitro and in vivo by regulating the expression of Thrombospondin 1 (THBS1) in an m6A-dependent manner, resulting in the recruitment of YTHDF2 to recognize and degrade THBS1 mRNA [31].