AKT1 and neoplasm: Lastly, the reduced levels of p-PI3K and p-Akt in the tumor tissues from 89-treated group corroborated the downregulation of 89 on PI3K/Akt signaling (Fig. 7K), which suggested that the tumor growth and metastasis inhibitory effect of 89 also correlated with the suppression of this pathway in vivo.