AKT1 and acute myeloid leukemia: Intriguingly, GFPT1-driven O-GlcNAcylation also modulates AKT activation [89, 90], as lower O-GlcNAcylation levels, induced by pharmacological inhibition of GFPT1 or OGT, correlate with heightened AKT phosphorylation at Ser473 and Thr308 in acute myeloid leukemia (AML) cells [91].