Moreover, GFPT2 contributes to M2 macrophage polarization in PDA cells through the GFPT2-O-GlcNAcylation-YBX1 axis [171], and LPS-triggered inflammatory signaling induces GFPT2 expression via TLR4-FoxO1 in macrophages and TNF-NF-κB in NSCLC [51, 172]. This evidence concerns the gene GFPT2 and non-small cell lung carcinoma.