Recent studies reveal a direct relationship between GFPT expression and immune cell infiltration in tumors, where GFPT has been shown to promote T-cell exhaustion and increase inhibitory immune checkpoints such as PD-L1/PD-1 in the tumor microenvironment, suggesting an immunosuppressive role [131, 148, 163–165]. The gene discussed is GFPT1; the disease is neoplasm.