Mitophagy, a selective form of autophagy, plays a crucial role in maintaining cellular homeostasis and facilitating stress adaptation.[74, 75] Previous studies have demonstrated that certain cancer cells exploit mitophagy as a survival mechanism to evade chemotherapy‐induced apoptosis.[76, 77] In our study, treatment with WSGC@FA@PEG/PEI‐SPIONs led to a marked downregulation of key mitophagy‐related proteins, including LC3, PINK1, and Parkin, effectively suppressing mitophagic activity in GA cells and reversing their chemotherapy resistance. This evidence concerns the gene PRKN and cancer.