Mitophagy, a selective form of autophagy, plays a crucial role in maintaining cellular homeostasis and facilitating stress adaptation.[74, 75] Previous studies have demonstrated that certain cancer cells exploit mitophagy as a survival mechanism to evade chemotherapy‐induced apoptosis.[76, 77] In our study, treatment with WSGC@FA@PEG/PEI‐SPIONs led to a marked downregulation of key mitophagy‐related proteins, including LC3, PINK1, and Parkin, effectively suppressing mitophagic activity in GA cells and reversing their chemotherapy resistance. The gene discussed is MAP1LC3A; the disease is cancer.