Previous studies have demonstrated that hyperactivation of Notch signaling enhances tumor cell proliferation, invasion, and chemoresistance,[59] while targeted inhibition of this pathway can sensitize tumor cells to chemotherapeutic agents.[60] Specifically, silencing of NOTCH1 has been shown to suppress GA cell growth and invasion, highlighting the therapeutic potential of Notch inhibition in overcoming drug resistance.[59] In the present study, we explored the effect of the WSGC peptide on chemotherapy resistance in GA and its regulation of the Notch signaling pathway. Here, NOTCH1 is linked to neoplasm.