Between ARGs_Low tumour cells and T cells, ITGB1-CD46 and ITGB1-ENG were ligand-receptor pairs with strong regulatory potential (Figure 8d), while COL1A2, CCL3, SERPINE1, FN1 and CDKN1A were top genes target to TGFB1 (Supplementary Figure 6B). The gene discussed is CDKN1A; the disease is neoplasm.