Between ARGs_High tumour cells and T cells, ITGB2-ICAM1 and TGFB1-TGFBR1 were ligand-receptor pairs with strong regulatory potential (Figure 8c), while EDN1, JUNB, SOCS3, VIM and COL1A2 were top genes target to TGFB1 (Supplementary Figure 6A). The gene discussed is EDN1; the disease is neoplasm.