HMGA1 and renal cell carcinoma: Shinichi and Meredith demonstrated that quinazoline-based drugs induce anoikis in RCC by disrupting survival signals in focal adhesions [21,62], while other studies showed that knockdown of HMGA1 and TIM-3 enhances anoikis occurrence [63], and silencing the tumour suppressor DLK1 increases anoikis resistance.