Between ARGs_High tumour cells and T cells, ITGB2-ICAM1 and TGFB1-TGFBR1 were ligand-receptor pairs with strong regulatory potential (Figure 8c), while EDN1, JUNB, SOCS3, VIM and COL1A2 were top genes target to TGFB1 (Supplementary Figure 6A). This evidence concerns the gene TGFBR1 and neoplasm.