TST and Dravet syndrome: Our data demonstrate that (a) DS rats have elevated blood cyanide levels; (b) DS tissues generate more cyanide than wild-type controls under both basal conditions and after glycine supplementation; (c) human DS fibroblasts produce higher cyanide levels than healthy control cells; and (d) this cyanide overproduction in DS is associated with a marked downregulation of TST (rhodanese), the key enzyme responsible for cyanide detoxification.