These proteins, along with modular calcium-binding protein 1 (SMOC1), which promotes platelet responsiveness to thrombin (69), PDGF, which promotes the calcification of vascular smooth muscle cells in atherosclerosis (70), and neutrophil-derived S100A8/A9, create a proinflammatory, proatherosclerotic milieu (14, 24, 69, 70, 71). The gene discussed is S100A8; the disease is atherosclerosis.