Turning to a human cell system with their IL-8 receptor/CD70CAR T (8R-70CAR T) cells and a CD70+ GBM cell line, the authors demonstrated that a commercially available anti–human LAIR1 antagonist antibody enhanced the CAR T antitumor response only in the presence of PBMC-derived M2-like macrophages. Here, CD70 is linked to glioblastoma.