These phenotypes, although divergent, align with the phenotype of Lmx1b mutant mouse models and NPS patient symptoms, indicating that these lines are relevant for the study of lmx1b. Although previous zebrafish studies have indicated differences between lmx1ba and lmx1bb expression during development (McMahon et al., 2009; Burzynski et al., 2013; He et al., 2014; Hilinski et al., 2016), here functional divergence between the paralogues is demonstrated and characterised across the whole body for the first time. The gene discussed is LMX1B; the disease is nail-patella syndrome.