In 2020, Qi and others reported that deficiency of A-kinase anchoring protein 121 (Akap1) in diabetic cardiomyopathy reduces mitochondrial complex I activity through inhibiting the translocation of NDUFS1 from cytosol to mitochondria, which decreases ATP production and increases mitochondrial ROS-mediated apoptosis [34]. The gene discussed is NDUFS1; the disease is diabetic cardiomyopathy.