Deletion of domain 71-185 results in unmodified localization in transfected cells whereas localization to speckles is lost in infected cells, indicating that binding to p32 is dispensable for the intrinsic property of pUL47 to associate to speckles but that, during infection, binding to p32 is necessary to maintain pUL47 in speckles or effectively transport it there. This evidence concerns the gene C1QBP and infection.