IL6 and endothelial dysfunction: The degree of microvascular dysfunction in ANOCA, INOCA, and MINOCA correlates with inflammatory markers, such as high-sensitivity CRP and soluble CD40 ligand.58-60 Endothelial dysfunction further exacerbates inflammation, promoting immune dysregulation and atherosclerotic progression, with key roles played by IL-1, IL-6, and TNF-α.61,62