IL6 and endothelial dysfunction: Following ischaemia, the myocardium exhibits a biphasic inflammatory response—an initial phase that worsens tissue injury, followed by a reparative phase involving regulatory T cells and M2 macrophages.31,32 IL-6 functions as a systemic mediator, promoting hepatic CRP production and contributing to endothelial dysfunction, adverse remodelling, and increased long-term cardiovascular risk.33