Circulating biomarkers of inflammation (C-reactive protein, ferritin, and 32 cytokines), immune depression (ex vivo tumor necrosis factor response to endotoxin < 200 pg/mL), thrombotic microangiopathy (ADAMTS13 activity <57%), and EBV seropositivity (viral capsid IgG) were measured. The gene discussed is TNF; the disease is Genetic thrombotic microangiopathy.