Moreover, some studies have directly implicated C99 in AD pathogenesis (Jordà‐Siquier et al., 2022; Lauritzen et al., 2019; Tompa, 2002), making it an important membrane protein for mechanistic and drug‐development studies (Takasugi et al., 2023) Previous studies have characterized C99 by reconstituting it in membrane‐mimicking environments that utilized detergent‐based methods to extract C99; hence, the native lipid‐protein interactions are likely to be lost (Krishnarjuna, Sharma, Hiiuk, et al., 2024; Motoki et al., 2012; Vetrivel et al., 2005). The gene discussed is APP; the disease is Alzheimer disease.