EDN1 and COVID-19: For predicting the need of ICU treatment only, TnT-hs and PCT could be better suited for non-COVID CAP [37], as they tend to capture cardiac stress and bacterial inflammation, while ET-1 might be more effective in COVID-19 due to its association with endothelial dysfunction caused e.g. by pulmonary endothelitis [38], pulmonary vasoconstriction, inflammation and thrombosis, which are a hallmark of COVID-19 [39].