UHRF1 and colorectal cancer: The most potentcompound was evaluated for its DNA methylation effects against theUHRF1-dependent colorectal cancer HCT116 cells, where promising globaldemethylating activity reaching an approximate 75% reduction comparedto control was achieved after treatment with 25 μM of NSC232005.Based on the presented results, rationally substituted analogues ofthe uracil scaffold appear as highly promising UHRF1 modulators forexploring its diverse functionalities and validating the protein asa drug target.