−, , ,  UHRF1 is currently identified as a key driving factorof several malignancies, such as melanoma, breast, bladder, colon,cervical, pancreatic and prostate cancer, leukemia, and lung or hepatocellularcarcinoma.,−, , , , , , ,  As such, UHRF1 comprises a highly promising target for therapeuticintervention. The various physiologicalfunctions of UHRF1 demonstrate a clear cell-cycle dependency thatis regulated by ubiquitination. Here, UHRF1 is linked to melanoma.