ATG16L1 and malignant colon neoplasm: Using HCT116 colon cancer cells homozygous for the T300 isoform or the A300 isoform of ATG16L1, we determined, comparing the signaling pathways activated by the drugs, that greater alterations in protein phosphorylation and protein expression were observed in T300/T300 cells compared to A300/A300 cells.