To assess the potential impact of ESRRA expression, we examined the rectal tissues using IHC in a cohort of 36 irradiated cancer patients, Notably, patients with reduced ESRRA expression experienced a higher incidence of moderate to severe diarrhea during radiotherapy, underscoring ESRRA’s potential role in mitigating radiation-induced gut damage (Table 1). The gene discussed is ESRRA; the disease is cancer.