CDNF has been shown to effectively mediate neuroprotection in models of Parkinson's disease (PD), Huntington's disease, stroke, amyotrophic lateral sclerosis, and cell death associated with ER stress (Eesmaa et al. 2022; Caglayan et al. 2023; De Lorenzo et al. 2023; Stepanova et al. 2023; Grote et al. 2024). The gene discussed is CDNF; the disease is Parkinson disease.