Given that IL‐17 knockout mice demonstrate reduced mechanical hyperalgesia in several animal models of arthritis (Ebbinghaus et al. 2017; Richter et al. 2012) and IL‐17 contributes to mechanical hypersensitivity following chemotherapy (Luo et al. 2019), we sought to translate our findings to the activation of colonic nociceptors by colorectal distension. This evidence concerns the gene IL17A and arthritic joint disease.