In contrast, our study found that puerarin administration decreased serum NOD-like receptor protein 3 (NLRP3) inflammasome and lipoprotein-associated phospholipase 2 (Lp-PLA2) levels while increasing C1q/TNF-Related Protein 3 (CTRP3) levels in elderly patients with coronary heart disease (CHD). This evidence concerns the gene C1QTNF3 and coronary artery disorder.