SPINK1 and pancreatitis: Therefore, we attempted to clarify whether pancreatitis-related genotypes are associated with R-FD. GPRC6A and SPINK1 genotypes were not significantly associated with FD symptoms and pancreatic enzyme abnormalities (Appendices 2, 3). In addition, the GPRC6A genotype was not associated with the BT-PABA test and HOMA-β, as exocrine and endocrine pancreatic dysfunction (Appendix 4).