Further studies are required to determine the association between SNPs of GPRC6A and SPINK1 and their activity. Thirdly, in this study, the GPRC6A genotype was not significantly associated with clinical symptoms and clinical characteristics of patients with R-FD. Fourthly, we could not identify populations carrying the variant allele of the SPINK1 gene. The gene discussed is GPRC6A; the disease is Fabry disease.