Additionally, soluble Fms-like tyrosine kinase-1 (sFlt-1) is increased in preeclampsia, which is an antiangiogenic factor that binds and inactivates PGF and vascular endothelial growth factor (VEGF), contributing to a reduction in endothelial repair and abnormal placentation [14]. The gene discussed is FLT1; the disease is preeclampsia.